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Through these pathways, all signal molecules would promote development of tumor directly or contribute to progress of various cancers indirectly by increasing tumor-associated macrophages, for instance promoting tumor growth, angiogenesis, extracellular matrix breakdown, invasion, and metastasis. Together with state of the art in the field, based on some of the most recent work, this paper will include a brief look on some results obtained by our group.

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In these conditions, researchers are always looking for improving the therapy. In this presentation, we mention the histological types of pancreatic cancer, the importance of systemic therapy for operable cases pre- and post-surgeryand of chemotherapy for advanced and metastatic cancer.

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Biopsy and FNAC are invasive procedures, especially in the case of deeply located tumors, and may present severe complications such as infection, bleeding, or inflammation. More importantly, they also carry the risk of seeding tumor cells around the sampling area.

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